Product
Advanced Pain Remedies, LLC is a biotechnology company developing APR 102, a conjugate consisting of the endogenous neuropeptide, substance P (SP), and a protein toxin, saporin (SAP). The product has shown efficacy in animal models of pain. APR 102 is a chemical conjugate of SP and a recombinant form of saporin, a protein toxin originally isolated from the plant Saponaria officinalis (soapwort), that inhibits eukaryotic protein synthesis. APR 102 selectively targets and eliminates NK1R-expressing neurons located in the dorsal horn of the spinal cord. Intrathecal delivery of APR 102 blocks transmission of chronic (neuropathic) pain to the brain. The effects are believed to be permanent.
Advanced Pain Remedies intends to develop APR 102 initially for the treatment of terminally ill patients who have intractable chronic pain.
Preclinical data have shown the following: (1) APR 102 greatly reduces neuropathic and inflammatory pain, (2) normal pain transmission is retained, (3) pain relief appears permanent with no collateral pain states, and (4) pain that occurs after treatment with APR 102 can still be treated with morphine or other analgesics.
